Spine & Arthritis · NEET PG Preparation Orthopaedics
A 32-year-old male presents with chronic inflammatory lower back pain, morning stiffness lasting more than one hour, and bilateral gluteal pain that…
Practice question from Spine & Arthritis (NEET PG Preparation Orthopaedics), with the correct answer and a step-by-step solution.
easy · MCQ · Q-0371C5
A 32-year-old male presents with chronic inflammatory lower back pain, morning stiffness lasting more than one hour, and bilateral gluteal pain that alternates sides. Radiography of the pelvis reveals bilateral sacroilitis. Which of the following is the hallmark genetic association for this condition?
- A.HLA-B27Correct answer
- B.HLA-DR4
- C.HLA-B51
- D.HLA-DQ2
Solution
The clinical presentation is classic for Ankylosing Spondylitis, a seronegative spondyloarthropathy characterized by chronic inflammation of the axial skeleton, entheses, and sacroiliac joints. It is strongly associated with the major histocompatibility complex class I allele HLA-B27.
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