Endocrinology · NEET PG Preparation Medicine
A 34-year-old woman presents with palpitations, weight loss, heat intolerance, and a tremor. Laboratory investigations reveal a suppressed TSH of <0.…
Practice question from Endocrinology (NEET PG Preparation Medicine), with the correct answer and a step-by-step solution.
easy · MCQ · Q-18484A
A 34-year-old woman presents with palpitations, weight loss, heat intolerance, and a tremor. Laboratory investigations reveal a suppressed TSH of <0.01 mIU/L, elevated free T4, and significantly elevated radioactive iodine uptake diffusely throughout the gland. She is diagnosed with Graves disease. Which of the following antibodies is the primary pathogenic driver of this condition?
- A.Anti-thyroid peroxidase (anti-TPO) antibodies
- B.Thyroid-stimulating hormone receptor antibodies (TRAb)Correct answer
- C.Anti-thyroglobulin antibodies
- D.Thyroid-stimulating immunoglobulin G Fc-receptor antibodies
Solution
Graves disease is an autoimmune disorder caused by the production of thyroid-stimulating hormone receptor antibodies (TRAb), specifically thyroid-stimulating immunoglobulins (TSI), which bind to and activate the TSH receptor, leading to hyperthyroidism and goiter. Anti-TPO and anti-thyroglobulin are characteristically elevated in Hashimoto thyroiditis.
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