Enzymes · NEET PG Preparation Biochemistry
A 45-year-old chronic alcoholic presents with peripheral neuropathy and severe memory impairment. Laboratory evaluation reveals a deficiency of thiam…
Practice question from Enzymes (NEET PG Preparation Biochemistry), with the correct answer and a step-by-step solution.
medium · MCQ · Q-694F2D
A 45-year-old chronic alcoholic presents with peripheral neuropathy and severe memory impairment. Laboratory evaluation reveals a deficiency of thiamine, leading to impaired functioning of the pyruvate dehydrogenase complex. Which of the following coenzymes is NOT required by this multi-enzyme complex?
- A.Thiamine pyrophosphate (TPP)
- B.Pyridoxal phosphate (PLP)Correct answer
- C.FAD (Flavin adenine dinucleotide)
- D.NAD+ (Nicotinamide adenine dinucleotide)
Solution
The pyruvate dehydrogenase complex requires five coenzymes: Thiamine pyrophosphate (TPP), Lipoamide, Coenzyme A, FAD, and NAD+. Pyridoxal phosphate (PLP) is a derivative of vitamin B6 and is typically involved in transamination and decarboxylation reactions of amino acids, not in the pyruvate dehydrogenase complex.
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