Cardiology · NEET PG Preparation Medicine
A 28-year-old competitive athlete collapses during a soccer match and is brought to the emergency department, where he is declared dead. Post-mortem…
Practice question from Cardiology (NEET PG Preparation Medicine), with the correct answer and a step-by-step solution.
medium · MCQ · Q-6BC730
A 28-year-old competitive athlete collapses during a soccer match and is brought to the emergency department, where he is declared dead. Post-mortem examination reveals disproportionate thickening of the interventricular septum compared to the left ventricular free wall, with myocyte disarray on histology. Which inheritance pattern and genetic locus category are most typically associated with this condition?
- A.Autosomal recessive; mitochondrial DNA mutations
- B.Autosomal dominant; mutations in genes encoding sarcomeric proteinsCorrect answer
- C.X-linked dominant; dystrophin gene mutations
- D.Autosomal dominant; genes encoding low-density lipoprotein receptors
Solution
Hypertrophic cardiomyopathy (HCM) is classically inherited as an autosomal dominant trait caused by mutations in genes encoding thick and thin filament proteins of the cardiac sarcomere (e.g., beta-myosin heavy chain, myosin-binding protein C).
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