Local & Regional Anaesthesia · NEET PG Preparation Anaesthesia
Which of the following local anaesthetics has the highest intrinsic lipid solubility and potency, and a strong tendency to bind to cardiac sodium cha…
Practice question from Local & Regional Anaesthesia (NEET PG Preparation Anaesthesia), with the correct answer and a step-by-step solution.
medium · MCQ · Q-774B04
Which of the following local anaesthetics has the highest intrinsic lipid solubility and potency, and a strong tendency to bind to cardiac sodium channels, making resuscitation from systemic toxicity particularly challenging?
- A.Lidocaine
- B.Mepivacaine
- C.BupivacaineCorrect answer
- D.Chloroprocaine
Solution
Bupivacaine is a highly lipid-soluble, potent local anaesthetic with slow dissociation from cardiac sodium channels during diastole, leading to cumulative blockade and severe cardiotoxicity. Lipid emulsion therapy is the specific antidote.
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