Bone Tumours · NEET PG Preparation Orthopaedics
A 16-year-old male presents with pain and swelling around the right knee for 3 months. Radiographs of the distal femur reveal a destructive, mixed ly…
Practice question from Bone Tumours (NEET PG Preparation Orthopaedics), with the correct answer and a step-by-step solution.
medium · MCQ · Q-9B32EF
A 16-year-old male presents with pain and swelling around the right knee for 3 months. Radiographs of the distal femur reveal a destructive, mixed lytic and sclerotic lesion in the metaphysis with periosteal reaction showing 'Codman triangle' and 'sunburst' appearance. Which of the following is the most characteristic histological feature of this tumor?
- A.Cartilaginous matrix with atypical chondrocytes
- B.Malignant osteoid production directly by tumor cellsCorrect answer
- C.Sheets of uniform round blue cells with glycogen granules
- D.Multinucleated giant cells evenly distributed among mononuclear stromal cells
Solution
The clinical presentation, age, location (metaphysis of distal femur), and radiological findings (sunburst appearance, Codman triangle) are classic for Osteosarcoma. The defining histological feature of osteosarcoma is the malignant production of osteoid (immature bone) directly by atypical spindle-shaped tumor cells.
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