Nose & Paranasal Sinuses · NEET PG Preparation ENT
A 50-year-old chronic smoker presents with a destructive midline facial lesion, crusting, nasal septal perforation, and a 'saddle nose' deformity. Bi…
Practice question from Nose & Paranasal Sinuses (NEET PG Preparation ENT), with the correct answer and a step-by-step solution.
hard · MCQ · Q-DEF62B
A 50-year-old chronic smoker presents with a destructive midline facial lesion, crusting, nasal septal perforation, and a 'saddle nose' deformity. Biopsy shows atypical inflammatory infiltrates and necrosis without definitive vasculitis. Laboratory tests show positivity for antineutrophil cytoplasmic antibodies (c-ANCA). What is the most appropriate diagnosis?
- A.Rhinoscleroma
- B.Granulomatosis with polyangiitisCorrect answer
- C.Lupus vulgaris
- D.Relapsing polychondritis
Solution
Granulomatosis with polyangiitis (formerly Wegener granulomatosis) characteristically presents with upper respiratory tract involvement (destructive sinonasal lesions, septal perforation, saddle nose deformity) and is classically associated with cytoplasmic ANCA (c-ANCA) positivity.
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