Nephrology · NEET PG Preparation Medicine
A 32-year-old woman presents with recurrent macroscopic hematuria, typically occurring 1-2 days following upper respiratory tract infections. Her ren…
Practice question from Nephrology (NEET PG Preparation Medicine), with the correct answer and a step-by-step solution.
easy · MCQ · Q-F04FFC
A 32-year-old woman presents with recurrent macroscopic hematuria, typically occurring 1-2 days following upper respiratory tract infections. Her renal function is normal, and she is normotensive. Serum complement levels (C3 and C4) are within normal limits. Which of the following is the gold standard method for definitive diagnosis of her condition?
- A.Ultrasonography of kidneys
- B.Renal biopsy with immunofluorescenceCorrect answer
- C.Measurement of serum IgA levels
- D.Antinuclear antibody (ANA) titer
Solution
The clinical presentation of recurrent gross hematuria following upper respiratory tract infections within 1-2 days is classic for IgA nephropathy (Berger disease). Although serum IgA levels may be elevated, they are neither sensitive nor specific enough for diagnosis. The definitive diagnosis is established by renal biopsy demonstrating mesangial IgA deposition predominantly on immunofluorescence microscopy.
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