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Respiratory Medicine · NEET PG Preparation Medicine

A 65-year-old male with a 40 pack-year smoking history presents with a 3-month history of cough and hemoptysis. Chest X-ray reveals a cavitary lesion…

Practice question from Respiratory Medicine (NEET PG Preparation Medicine), with the correct answer and a step-by-step solution.

easy · MCQ · Q-098CE3

A 65-year-old male with a 40 pack-year smoking history presents with a 3-month history of cough and hemoptysis. Chest X-ray reveals a cavitary lesion in the right upper lobe with thick, irregular walls. Sputum cytology is suspicious for squamous cell carcinoma. Which of the following paraneoplastic syndromes is most characteristically associated with this specific histological subtype?

  1. A.Hyponatremia secondary to SIADH
  2. B.Hypercalcemia secondary to PTH-related protein (PTHrP) secretionCorrect answer
  3. C.Cushing syndrome due to ectopic ACTH production
  4. D.Lambert-Eaton myasthenic syndrome

Solution

Squamous cell carcinoma of the lung is centrally located and frequently undergoes cavitation. It is classically associated with hypercalcemia mediated by tumor secretion of parathyroid hormone-related protein (PTHrP). SIADH, ectopic ACTH, and Lambert-Eaton syndrome are classically associated with small cell lung cancer.

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