Carbohydrate Metabolism · NEET PG Preparation Biochemistry

Which of the following regulatory molecules acts as a potent allosteric activator of phosphofructokinase-1 (PFK-1) in the liver, signaling a high ene…

Practice question from Carbohydrate Metabolism (NEET PG Preparation Biochemistry), with the correct answer and a step-by-step solution.

easy · MCQ · Q-2DF1D3

Which of the following regulatory molecules acts as a potent allosteric activator of phosphofructokinase-1 (PFK-1) in the liver, signaling a high energy state and abundance of carbon skeletons for glycolysis?

  1. A.ATP
  2. B.Citrate
  3. C.Fructose-2,6-bisphosphateCorrect answer
  4. D.Glucose-6-phosphate

Solution

Fructose-2,6-bisphosphate is the most potent allosteric activator of PFK-1, overriding the inhibitory effects of ATP and citrate to stimulate glycolysis.

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