Rheumatology · NEET PG Preparation Medicine
A 60-year-old man presents with sudden onset of excruciating pain, swelling, and erythema of the first metatarsophalangeal joint. Arthrocentesis of t…
Practice question from Rheumatology (NEET PG Preparation Medicine), with the correct answer and a step-by-step solution.
easy · MCQ · Q-41FAA7
A 60-year-old man presents with sudden onset of excruciating pain, swelling, and erythema of the first metatarsophalangeal joint. Arthrocentesis of the joint reveals negatively birefringent needle-shaped crystals under polarized light microscopy. Which of the following is the primary pathophysiological abnormality responsible for this condition?
- A.Deposition of calcium pyrophosphate crystals
- B.Deposition of monosodium urate crystalsCorrect answer
- C.Deposition of basic calcium phosphate crystals
- D.Deposition of cholesterol crystals
Solution
Gout is caused by the deposition of monosodium urate crystals in and around joints, which appear as needle-shaped with negative birefringence on polarized light microscopy. Calcium pyrophosphate deposition disease (pseudogout) shows positively birefringent rhomboid crystals.
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