Gastrointestinal Physiology · NEET PG Preparation Physiology
A 52-year-old woman undergoes total gastrectomy for gastric adenocarcinoma. Postoperatively, she is at high risk for developing macrocytic anemia due…
Practice question from Gastrointestinal Physiology (NEET PG Preparation Physiology), with the correct answer and a step-by-step solution.
easy · MCQ · Q-422144
A 52-year-old woman undergoes total gastrectomy for gastric adenocarcinoma. Postoperatively, she is at high risk for developing macrocytic anemia due to a deficiency in which of the following substances normally secreted by the stomach?
- A.Hydrochloric acid
- B.Intrinsic factorCorrect answer
- C.Pepsinogen
- D.Gastrin
Solution
Intrinsic factor is a glycoprotein secreted by the parietal cells of the gastric mucosa, which is essential for the ileal absorption of vitamin B12. Total gastrectomy results in total loss of intrinsic factor production, leading to pernicious/macrocytic anemia unless lifelong parenteral B12 supplementation is provided.
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