Toxicology · NEET PG Preparation Forensic Medicine
A 35-year-old agricultural worker presents with excessive salivation, lacrimation, urination, diarrhea, gastrointestinal cramps, and miosis after spr…
Practice question from Toxicology (NEET PG Preparation Forensic Medicine), with the correct answer and a step-by-step solution.
easy · MCQ · Q-66669E
A 35-year-old agricultural worker presents with excessive salivation, lacrimation, urination, diarrhea, gastrointestinal cramps, and miosis after spraying crops. Which of the following is the primary mechanism of action of the suspected poison?
- A.Irreversible inhibition of acetylcholinesteraseCorrect answer
- B.Competitive antagonism at muscarinic receptors
- C.Blockade of voltage-gated sodium channels in nerve axons
- D.Uncoupling of oxidative phosphorylation
Solution
The patient presents with classical symptoms of organophosphate poisoning (DUMBELS: Diarrhea, Urination, Miosis, Bronchospasm/Bradycardia, Emesis, Lacrimation, Salivation). Organophosphates cause poisoning through the irreversible phosphorylation and inhibition of the enzyme acetylcholinesterase, leading to an accumulation of acetylcholine at muscarinic and nicotinic receptors.
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