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Neonatology · NEET PG Preparation Paediatrics

A term male neonate presents on the 3rd day of life with generalized tonic-clonic seizures. He was born at home and did not receive Vitamin K prophyl…

Practice question from Neonatology (NEET PG Preparation Paediatrics), with the correct answer and a step-by-step solution.

medium · MCQ · Q-998018

A term male neonate presents on the 3rd day of life with generalized tonic-clonic seizures. He was born at home and did not receive Vitamin K prophylaxis at birth. Laboratory investigations reveal a hemoglobin of 10 g/dL, platelet count of 250,000/uL, prothrombin time (PT) of > 100 seconds, and activated partial thromboplastin time (aPTT) significantly prolonged. Cranial ultrasound shows a massive intracranial hemorrhage. What is the most likely diagnosis?

  1. A.Early vitamin K deficiency bleeding
  2. B.Classic vitamin K deficiency bleeding
  3. C.Late vitamin K deficiency bleedingCorrect answer
  4. D.Disseminated intravascular coagulation

Solution

Late vitamin K deficiency bleeding (VKDB) typically presents between 2 to 12 weeks (up to 6 months) of life, most commonly with intracranial hemorrhage in exclusively breastfed infants who did not receive vitamin K prophylaxis at birth. It is characterized by prolonged PT and normal platelet count.

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