Menstrual Disorders & Infertility · NEET PG Preparation Obstetrics & Gynaecology

A 34-year-old woman with a history of regular cycles presents with secondary amenorrhea for 6 months. Her serum prolactin level is significantly elev…

Practice question from Menstrual Disorders & Infertility (NEET PG Preparation Obstetrics & Gynaecology), with the correct answer and a step-by-step solution.

easy · MCQ · Q-9B971F

A 34-year-old woman with a history of regular cycles presents with secondary amenorrhea for 6 months. Her serum prolactin level is significantly elevated at 120 ng/mL120 \text{ ng/mL} (normal < 20 ng/mL20 \text{ ng/mL}). She is not taking any medications and her TSH is normal. Magnetic resonance imaging (MRI) of the brain reveals a microadenoma of the pituitary gland (6 mm6 \text{ mm}). What is the most appropriate initial treatment?

  1. A.Transsphenoidal surgical resection
  2. B.Dopamine agonist therapy (e.g., Cabergoline or Bromocriptine)Correct answer
  3. C.Observation and repeat MRI in 5 years
  4. D.External beam radiation therapy

Solution

Hyperprolactinemia due to a prolactin-secreting pituitary microadenoma is treated medically with dopamine agonists (cabergoline or bromocriptine). Cabergoline is preferred due to higher efficacy and lower side effect profile. Surgery is reserved for medical treatment failure or visual compromise.

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