Substance Use Disorders · NEET PG Preparation Psychiatry
Which of the following pharmacotherapeutic agents acts as an irreversible inhibitor of aldehyde dehydrogenase, causing an unpleasant physiological re…
Practice question from Substance Use Disorders (NEET PG Preparation Psychiatry), with the correct answer and a step-by-step solution.
easy · MCQ · Q-B1EAEE
Which of the following pharmacotherapeutic agents acts as an irreversible inhibitor of aldehyde dehydrogenase, causing an unpleasant physiological reaction characterized by flushing, headache, nausea, and vomiting when alcohol is consumed?
- A.Naltrexone
- B.Acamprosate
- C.DisulfiramCorrect answer
- D.Methadone
Solution
Disulfiram acts as an aversion therapy agent by inhibiting aldehyde dehydrogenase, leading to an accumulation of acetaldehyde if alcohol is ingested, which causes the classic disulfiram-ethanol reaction (flushing, throbbing headache, dyspnea, nausea, vomiting, hypotension).
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