Complications of Pregnancy · NEET PG Preparation Obstetrics & Gynaecology
A 32-year-old woman at 12 weeks of gestation presents with vaginal bleeding and passage of grape-like tissue. Ultrasound reveals a 'snowstorm' appear…
Practice question from Complications of Pregnancy (NEET PG Preparation Obstetrics & Gynaecology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-BD4C5F
A 32-year-old woman at 12 weeks of gestation presents with vaginal bleeding and passage of grape-like tissue. Ultrasound reveals a 'snowstorm' appearance with no fetal parts. Serum beta-hCG is >100,000 mIU/mL, and bilateral ovarian enlargement is noted. What is the most common cytogenetic profile of this complete hydatidiform mole?
- A.69,XXY (Triploid)
- B.46,XX (Androgenetic)Correct answer
- C.46,XY (Biparental)
- D.45,X0
Solution
A complete hydatidiform mole is typically diploid (46,XX) and arises from an empty egg fertilized by a single sperm that subsequently duplicates its own chromosomes (androgenetic origin). Partial moles are usually triploid (69,XXX or 69,XXY) resulting from dispermic fertilization of a normal egg.
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