Endocrinology & Reproduction · NEET PG Preparation Physiology
During the mid-menstrual cycle surge of gonadotropins, which of the following paradoxical feedback effects does estrogen exert on the anterior pituit…
Practice question from Endocrinology & Reproduction (NEET PG Preparation Physiology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-DEE476
During the mid-menstrual cycle surge of gonadotropins, which of the following paradoxical feedback effects does estrogen exert on the anterior pituitary and hypothalamus?
- A.Negative feedback inhibition of both FSH and LH
- B.Positive feedback stimulation of both FSH and LH secretionCorrect answer
- C.Inhibition of GnRH pulse frequency while stimulating GnRH amplitude
- D.Direct suppression of pituitary gonadotroph responsiveness
Solution
Throughout most of the ovarian cycle, estrogen exerts negative feedback on gonadotropin secretion. However, just before ovulation, sustained high levels of estrogen (above a critical threshold for more than 36 hours) exert a paradoxical positive feedback effect, triggering the massive preovulatory luteinizing hormone (LH) and follicle-stimulating hormone (FSH) surge.
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