Radiotherapy & Nuclear Medicine · NEET PG Preparation Radiology
Which of the following radioisotopes is most commonly used for targeted radionuclide therapy in metastatic castration-resistant prostate cancer with…
Practice question from Radiotherapy & Nuclear Medicine (NEET PG Preparation Radiology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-FFAEF2
Which of the following radioisotopes is most commonly used for targeted radionuclide therapy in metastatic castration-resistant prostate cancer with bone metastases, primarily acting as an alpha emitter?
- A.Iodine-131
- B.Lutetium-177
- C.Radium-223Correct answer
- D.Strontium-89
Solution
Radium-223 dichloride is an alpha-emitting bone-seeking radionuclide approved for the treatment of patients with castration-resistant prostate cancer and symptomatic bone metastases. Alpha particles have a very short range (a few cell diameters) and high linear energy transfer (LET), causing potent double-stranded DNA breaks in adjacent tumor cells while minimizing bone marrow toxicity.
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