Papulosquamous & Vesiculobullous Disorders

Topics in this chapter

• Psoriasis and Papulosquamous Disorders
• Lichen Planus and Pityriasis Rosea
• Autoimmune Blistering Disorders
• Dermatitis Herpetiformis and Celiac Disease
• Epidermolysis Bullosa Acquisita
• Cutaneous Drug Reactions
• Superficial Fungal Disorders

Practice questions

1. Question 1Q-1DDEE9

   A 35-year-old man presents with well-demarcated erythematous plaques covered by silvery-white scales predominantly on his extensor surfaces and scalp. Which of the following histological findings is most characteristic of this condition?

   1. A.Suprabasal clefting with acantholysis
   2. B.Subepidermal blister with eosinophils
   3. C.Acanthosis with Munro microabscesses and parakeratosis
   4. D.Dyskeratosis and civatte bodies in the lower epidermis
   See the answer and solution
2. Question 2Q-EC851B

   A 45-year-old woman develops multiple flaccid bullae and erosions on her trunk and oral mucosa. Gentle lateral pressure on the skin causes detachment of the epidermis. Which of the following antibodies is primarily pathogenic in this disorder?

   1. A.Anti-Desmoglein 1 and 3
   2. B.Anti-BP180 and BP230
   3. C.Anti-Type VII collagen
   4. D.Anti-Desmoplakin
   See the answer and solution
3. Question 3Q-B2A100

   A 60-year-old male presents with tense blisters over his abdomen and flexural surfaces of the limbs. There is no mucosal involvement. Direct immunofluorescence of perilesional skin reveals linear IgG and C3 deposition along the epidermal basement membrane zone. What is the diagnosis?

   1. A.Pemphigus vulgaris
   2. B.Bullous pemphigoid
   3. C.Dermatitis herpetiformis
   4. D.Epidermolysis bullosa acquisita
   See the answer and solution
4. Question 4Q-E9821D

   A 25-year-old medical student develops a solitary, oval, fawn-colored, scaly plaque with a collarette of scale on his back, which was preceded 10 days earlier by a larger similar plaque. Within a week, multiple smaller secondary lesions appear along Langer lines in a 'fir-tree' distribution. What is the diagnosis and expected course?

   1. A.Tinea corporis; requires systemic antifungals
   2. B.Pityriasis rosea; self-limiting within 4-8 weeks
   3. C.Guttate psoriasis; lifelong chronic relapsing condition
   4. D.Secondary syphilis; requires benzathine penicillin
   See the answer and solution
5. Question 5Q-C6A5F7

   A 30-year-old patient presents with intensely pruritic, grouped papules and vesicles distributed symmetrically on the extensor surfaces of the elbows, knees, and buttocks. Biopsy reveals neutrophilic microabscesses in the dermal papillae. What is the most likely associated systemic condition?

   1. A.Systemic Lupus Erythematosus
   2. B.Celiac disease
   3. C.Inflammatory bowel disease
   4. D.Rheumatoid arthritis
   See the answer and solution