Papulosquamous & Vesiculobullous Disorders · NEET PG Preparation Dermatology
A 45-year-old woman develops multiple flaccid bullae and erosions on her trunk and oral mucosa. Gentle lateral pressure on the skin causes detachment…
Practice question from Papulosquamous & Vesiculobullous Disorders (NEET PG Preparation Dermatology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-EC851B
A 45-year-old woman develops multiple flaccid bullae and erosions on her trunk and oral mucosa. Gentle lateral pressure on the skin causes detachment of the epidermis. Which of the following antibodies is primarily pathogenic in this disorder?
- A.Anti-Desmoglein 1 and 3Correct answer
- B.Anti-BP180 and BP230
- C.Anti-Type VII collagen
- D.Anti-Desmoplakin
Solution
The clinical presentation (flaccid bullae, mucosal involvement, positive Nikolsky sign) is characteristic of Pemphigus Vulgaris, which is caused by autoantibodies against desmoglein 1 and desmoglein 3, leading to intraepidermal acantholysis.
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