Papulosquamous & Vesiculobullous Disorders · NEET PG Preparation Dermatology
A 60-year-old male presents with tense blisters over his abdomen and flexural surfaces of the limbs. There is no mucosal involvement. Direct immunofl…
Practice question from Papulosquamous & Vesiculobullous Disorders (NEET PG Preparation Dermatology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-B2A100
A 60-year-old male presents with tense blisters over his abdomen and flexural surfaces of the limbs. There is no mucosal involvement. Direct immunofluorescence of perilesional skin reveals linear IgG and C3 deposition along the epidermal basement membrane zone. What is the diagnosis?
- A.Pemphigus vulgaris
- B.Bullous pemphigoidCorrect answer
- C.Dermatitis herpetiformis
- D.Epidermolysis bullosa acquisita
Solution
Bullous pemphigoid typically presents with tense bullae in elderly patients without mucosal involvement. Direct immunofluorescence characteristically shows linear IgG and C3 deposits at the basement membrane zone targeting BP180 and BP230.
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