Immunology · NEET PG Preparation Microbiology
During negative selection in the thymic cortex and medulla, developing thymocytes that recognize self-antigens presented by cortical and medullary th…
Practice question from Immunology (NEET PG Preparation Microbiology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-10142B
During negative selection in the thymic cortex and medulla, developing thymocytes that recognize self-antigens presented by cortical and medullary thymic epithelial cells with high affinity undergo which of the following fates?
- A.Positive selection
- B.Clonal anergy
- C.Apoptosis (programmed cell death)Correct answer
- D.Receptor editing
Solution
Negative selection (clonal deletion) eliminates self-reactive T cells by inducing apoptosis in thymocytes that bind self-peptide-MHC complexes with high affinity. Positive selection rescues thymocytes with low-to-moderate affinity for self-MHC. Receptor editing is a feature of B cells, not T cells.
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