Immunology · NEET PG Preparation Microbiology
A 4-year-old boy presents with recurrent skin abscesses caused by Staphylococcus aureus and deep-seated fungal infections with Aspergillus. Nitroblue…
Practice question from Immunology (NEET PG Preparation Microbiology), with the correct answer and a step-by-step solution.
easy · MCQ · Q-D0B483
A 4-year-old boy presents with recurrent skin abscesses caused by Staphylococcus aureus and deep-seated fungal infections with Aspergillus. Nitroblue tetrazolium (NBT) test is abnormal (fails to turn blue), and dihydrorhodamine (DHR) flow cytometry test demonstrates a severe defect in neutrophil oxidative burst. Which enzyme complex is defective in this patient?
- A.Myeloperoxidase
- B.Phagocyte NADPH oxidaseCorrect answer
- C.Glucose-6-phosphate dehydrogenase
- D.Inducible nitric oxide synthase
Solution
The clinical presentation and abnormal NBT/DHR tests are diagnostic of Chronic Granulomatous Disease (CGD), which is caused by a defect in the phagocyte NADPH oxidase complex responsible for generating superoxide radicals during the respiratory burst.
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