Neoplasia · NEET PG Preparation Pathology
A researcher is studying the chemical carcinogenesis pathway in a laboratory model. Exposure to an ultimate carcinogen typically leads to direct cova…
Practice question from Neoplasia (NEET PG Preparation Pathology), with the correct answer and a step-by-step solution.
easy · MCQ · Q-23543A
A researcher is studying the chemical carcinogenesis pathway in a laboratory model. Exposure to an ultimate carcinogen typically leads to direct covalent binding with cellular macromolecules. Which of the following is the primary target for most chemical carcinogens leading to malignant transformation?
- A.Cellular membrane phospholipids
- B.Nuclear DNACorrect answer
- C.Ribosomal RNA
- D.Cytoplasmic structural proteins
Solution
Chemical carcinogens (such as alkylating agents, polycyclic aromatic hydrocarbons) undergo metabolic activation to ultimate carcinogens, which are electrophiles that react with nucleophilic sites in cellular macromolecules. Nuclear DNA is the critical target, causing mutations in proto-oncogenes and tumor suppressor genes.
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