Neoplasia · NEET PG Preparation Pathology
A 54-year-old chronic smoker presents with a central lung mass. Biopsy reveals small, dark, round-to-oval cells with scanty cytoplasm, finely granula…
Practice question from Neoplasia (NEET PG Preparation Pathology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-3F9D43
A 54-year-old chronic smoker presents with a central lung mass. Biopsy reveals small, dark, round-to-oval cells with scanty cytoplasm, finely granular chromatin, and absent nucleoli. Immunohistochemistry is positive for chromogranin and synaptophysin. Which of the following paraneoplastic syndromes is most characteristically associated with this specific tumor?
- A.Hypercalcemia due to PTH-related protein secretion
- B.Lambert-Eaton myasthenic syndrome due to antibodies against presynaptic voltage-gated calcium channelsCorrect answer
- C.Polycythemia due to erythropoietin production
- D.Hypoglycemia due to insulin-like growth factor secretion
Solution
Small cell carcinoma of the lung is a neuroendocrine tumor frequently associated with paraneoplastic syndromes, most notably Lambert-Eaton myasthenic syndrome (antibodies against presynaptic voltage-gated calcium channels) and SIADH or Cushing syndrome (due to ectopic ACTH). Hypercalcemia is classically linked to squamous cell carcinoma of the lung.
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