Neoplasia · NEET PG Preparation Pathology
Which of the following classic translocation events is correctly paired with its resulting fusion oncogene and corresponding hematologic malignancy?
Practice question from Neoplasia (NEET PG Preparation Pathology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-D4BB65
Which of the following classic translocation events is correctly paired with its resulting fusion oncogene and corresponding hematologic malignancy?
- A.t(8;14) - MYC/IGH - Chronic Myeloid Leukemia
- B.t(9;22) - BCR/ABL1 - Acute Promyelocytic Leukemia
- C.t(15;17) - PML/RARA - Acute Promyelocytic LeukemiaCorrect answer
- D.t(11;14) - BCL2/IGH - Burkitt Lymphoma
Solution
The translocation t(15;17) results in the PML/RARA fusion gene, characteristic of Acute Promyelocytic Leukemia (M3 AML). t(8;14) involves MYC/IGH in Burkitt lymphoma. t(9;22) involves BCR/ABL1 in CML and ALL. t(11;14) involves CCND1(Cyclin D1)/IGH in Mantle cell lymphoma.
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