Molecular Biology & Genetics · NEET PG Preparation Biochemistry
During DNA replication in eukaryotes, which of the following enzymes is primarily responsible for the removal of RNA primers and filling the resultin…
Practice question from Molecular Biology & Genetics (NEET PG Preparation Biochemistry), with the correct answer and a step-by-step solution.
hard · MCQ · Q-25A197
During DNA replication in eukaryotes, which of the following enzymes is primarily responsible for the removal of RNA primers and filling the resulting gaps on the lagging strand?
- A.DNA polymerase alpha-primase complex
- B.DNA polymerase delta with FEN1 and RNase HCorrect answer
- C.DNA polymerase gamma
- D.Topoisomerase II
Solution
In eukaryotes, DNA polymerase delta synthesizes the lagging strand and works in conjunction with RNase H1 and FEN1 (Flap Endonuclease 1) to remove RNA primers. DNA polymerase alpha-primase initiates replication by synthesizing an RNA-DNA hybrid primer. DNA polymerase gamma is mitochondrial. Topoisomerase II resolves topological stress.
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