Molecular Biology & Genetics · NEET PG Preparation Biochemistry
A researcher is studying a novel antibiotic that inhibits bacterial transcription by specifically binding to the beta subunit of RNA polymerase, prev…
Practice question from Molecular Biology & Genetics (NEET PG Preparation Biochemistry), with the correct answer and a step-by-step solution.
easy · MCQ · Q-E1DB33
A researcher is studying a novel antibiotic that inhibits bacterial transcription by specifically binding to the beta subunit of RNA polymerase, preventing the formation of phosphodiester bonds after the first few nucleotides are joined. Which antibiotic is this?
- A.RifampicinCorrect answer
- B.Actinomycin D
- C.Streptomycin
- D.Chloramphenicol
Solution
Rifampicin binds to the bacterial RNA polymerase beta subunit and inhibits transcription initiation (prevents elongation after formation of the first few phosphodiester bonds). Actinomycin D intercalates into GC-rich DNA, blocking elongation in both prokaryotes and eukaryotes. Streptomycin and chloramphenicol are translation inhibitors.
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