Antimicrobials · NEET PG Preparation Pharmacology
A 45-year-old female presents with acute pyelonephritis. Urine culture grows Escherichia coli resistant to multiple drugs. She is prescribed a fluoro…
Practice question from Antimicrobials (NEET PG Preparation Pharmacology), with the correct answer and a step-by-step solution.
easy · MCQ · Q-38D174
A 45-year-old female presents with acute pyelonephritis. Urine culture grows Escherichia coli resistant to multiple drugs. She is prescribed a fluoroquinolone. Which of the following is the primary intracellular target of fluoroquinolones in gram-negative bacteria?
- A.DNA gyrase (topoisomerase II) and topoisomerase IVCorrect answer
- B.RNA polymerase beta-subunit
- C.30S ribosomal subunit
- D.PBP2a (Penicillin-binding protein 2a)
Solution
Fluoroquinolones target bacterial DNA gyrase (predominantly in gram-negative organisms) and topoisomerase IV (predominantly in gram-positive organisms), inhibiting DNA replication and transcription.
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