Antimicrobials · NEET PG Preparation Pharmacology
Which of the following anti-tubercular drugs is uniquely bactericidal against both actively dividing and slow-replicating semi-dormant tubercle bacil…
Practice question from Antimicrobials (NEET PG Preparation Pharmacology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-5C09C5
Which of the following anti-tubercular drugs is uniquely bactericidal against both actively dividing and slow-replicating semi-dormant tubercle bacilli residing within acidic intracellular environments (caseous lesions)?
- A.Isoniazid
- B.Ethambutol
- C.PyrazinamideCorrect answer
- D.Streptomycin
Solution
Pyrazinamide is a prodrug converted to pyrazinoic acid, which works best in the acidic environment of macrophage lysosomes/caseous granulomas where semi-dormant tubercle bacilli reside.
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