Haematology · NEET PG Preparation Pathology
A 65-year-old man presents with generalized lymphadenopathy and hepatosplenomegaly. Complete blood count shows a total leukocyte count of 95,000/uL w…
Practice question from Haematology (NEET PG Preparation Pathology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-5589FA
A 65-year-old man presents with generalized lymphadenopathy and hepatosplenomegaly. Complete blood count shows a total leukocyte count of 95,000/uL with 85% mature-appearing lymphocytes. Peripheral smear shows numerous 'smudge cells'. Flow cytometry reveals clonal B cells expressing CD19, CD20, CD23, and weak surface immunoglobulin, along with low-intensity CD5. What is the diagnosis?
- A.Chronic lymphocytic leukemiaCorrect answer
- B.Hairy cell leukemia
- C.Mantle cell lymphoma
- D.Acute lymphoblastic leukemia
Solution
Chronic lymphocytic leukemia (CLL) is characterized by an accumulation of mature-appearing B cells that are positive for CD5, CD19, CD20, and CD23, accompanied by characteristic smudge cells on the peripheral smear.
More from Haematology
- A 24-year-old female presents with fatigue and jaundice. Peripheral blood smear reveals spherocytes and polychromasia. Osmotic fragility is…
- A 4-year-old boy is brought with recurrent hemarthrosis and deep muscle hematomas. Laboratory investigations reveal a prolonged aPTT with a…
- A 50-year-old male presents with fatigue, splenomegaly, and night sweats. Complete blood count shows leukocytosis with a full spectrum of m…
- A bone marrow aspirate from a 60-year-old patient with pancytopenia shows 35% myeloblasts containing distinct red-purple, needle-like cytop…
Practise more Pathology
Sign up free for adaptive practice on this chapter, with instant feedback and hints on every question.
Start practising freeFree to start · No credit card needed