Haematology · NEET PG Preparation Pathology
A 50-year-old male presents with fatigue, splenomegaly, and night sweats. Complete blood count shows leukocytosis with a full spectrum of myeloid cel…
Practice question from Haematology (NEET PG Preparation Pathology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-906DD5
A 50-year-old male presents with fatigue, splenomegaly, and night sweats. Complete blood count shows leukocytosis with a full spectrum of myeloid cells in the peripheral blood, including myelocytes, metamyelocytes, bands, and segmented neutrophils, along with basophilia. Bone marrow is hypercellular. Cytogenetic analysis reveals a translocation t(9;22)(q34;q11). Which of the following enzymes is constitutively activated by this genetic lesion?
- A.Tyrosine kinaseCorrect answer
- B.Serine/threonine kinase
- C.DNA polymerase
- D.Histone deacetylase
Solution
The t(9;22) translocation results in the Philadelphia chromosome, creating the BCR-ABL fusion gene. BCR-ABL encodes a chimeric protein with constitutively active tyrosine kinase activity, characteristic of Chronic Myeloid Leukemia (CML).
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