Schizophrenia & Psychosis · NEET PG Preparation Psychiatry
A 28-year-old male is evaluated for prominent negative symptoms of schizophrenia. Which of the following atypical antipsychotics is characterized by…
Practice question from Schizophrenia & Psychosis (NEET PG Preparation Psychiatry), with the correct answer and a step-by-step solution.
medium · MCQ · Q-9919B6
A 28-year-old male is evaluated for prominent negative symptoms of schizophrenia. Which of the following atypical antipsychotics is characterized by a high affinity for serotonin 5-HT2A receptors relative to dopamine D2 receptors, along with significant antagonism at 5-HT2C, alpha-1 adrenergic, and histamine H1 receptors?
- A.Haloperidol
- B.OlanzapineCorrect answer
- C.Pimozide
- D.Fluphenazine
Solution
Olanzapine is an atypical antipsychotic with high affinity for serotonin 5-HT2A and dopamine D2 receptors, as well as antagonism at muscarinic, histamine H1, and alpha-1 adrenergic receptors. Haloperidol, pimozide, and fluphenazine are typical antipsychotics (high-potency D2 blockers).
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