Immunopathology · NEET PG Preparation Pathology
A 32-year-old woman presents with malar rash, arthralgia, and generalized fatigue. Laboratory investigations reveal positive anti-nuclear antibodies…
Practice question from Immunopathology (NEET PG Preparation Pathology), with the correct answer and a step-by-step solution.
easy · MCQ · Q-9A8613
A 32-year-old woman presents with malar rash, arthralgia, and generalized fatigue. Laboratory investigations reveal positive anti-nuclear antibodies (ANA) and anti-double-stranded DNA (anti-dsDNA) antibodies. Renal biopsy shows 'wire-loop' lesions of the glomerular capillaries by light microscopy. Which type of hypersensitivity reaction is primarily responsible for the glomerular injury in this condition?
- A.Type I hypersensitivity
- B.Type II hypersensitivity
- C.Type III hypersensitivityCorrect answer
- D.Type IV hypersensitivity
Solution
Systemic Lupus Erythematosus (SLE) is the classic prototype of a Type III hypersensitivity reaction, which is mediated by the deposition of circulating immune complexes (antigen-antibody complexes) in tissues such as glomeruli, causing complement activation and subsequent tissue damage.
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