Immunopathology · NEET PG Preparation Pathology
A 30-year-old woman presents with progressive fatigue, muscle weakness that worsens with repetitive activity, and double vision by the end of the day…
Practice question from Immunopathology (NEET PG Preparation Pathology), with the correct answer and a step-by-step solution.
easy · MCQ · Q-B62751
A 30-year-old woman presents with progressive fatigue, muscle weakness that worsens with repetitive activity, and double vision by the end of the day. Edrophonium test provides immediate, temporary relief of her symptoms. The underlying immunopathological mechanism involves autoantibodies directed against which specific target?
- A.Voltage-gated calcium channels at the presynaptic membrane
- B.Postsynaptic nicotinic acetylcholine receptorsCorrect answer
- C.Acetylcholinesterase enzyme in the synaptic cleft
- D.Myelin basic protein of peripheral nerves
Solution
Myasthenia gravis is a Type II hypersensitivity disorder characterized by autoantibodies against the postsynaptic nicotinic acetylcholine receptors at the neuromuscular junction, leading to complement-mediated damage and receptor internalization.
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