Vitamins & Minerals · NEET PG Preparation Biochemistry
A 45-year-old chronic alcoholic is brought to the emergency department with acute confusion, ataxia, and ophthalmoplegia. Which of the following enzy…
Practice question from Vitamins & Minerals (NEET PG Preparation Biochemistry), with the correct answer and a step-by-step solution.
medium · MCQ · Q-9B6CEA
A 45-year-old chronic alcoholic is brought to the emergency department with acute confusion, ataxia, and ophthalmoplegia. Which of the following enzymes is most likely inhibited or impaired in this patient due to a vitamin cofactor deficiency?
- A.Glucose-6-phosphate dehydrogenase
- B.TransketolaseCorrect answer
- C.Methylmalonyl-CoA mutase
- D.Homocysteine methyltransferase
Solution
The clinical presentation describes Wernicke-Korsakoff syndrome, caused by thiamine (Vitamin B1) deficiency. Thiamine pyrophosphate is an essential cofactor for transketolase (in the HMP shunt), as well as pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase.
More from Vitamins & Minerals
- A 3-year-old child presents with night blindness and Bitot spots on the conjunctiva. Dietary history reveals a predominantly cereal-based d…
- An exclusive breastfed 6-month-old infant presents with craniotabs, delayed closure of the anterior fontanelle, and widening of the wrists.…
- A patient presents with megaloblastic anemia, but serum levels of folate and vitamin B12 are within normal limits. Further investigation re…
- A 50-year-old man with chronic renal failure presents with bone pain and proximal muscle weakness. Laboratory studies show hyperphosphatemi…
Practise more Biochemistry
Sign up free for adaptive practice on this chapter, with instant feedback and hints on every question.
Start practising freeFree to start · No credit card needed