Vitamins & Minerals · NEET PG Preparation Biochemistry
A 50-year-old man with chronic renal failure presents with bone pain and proximal muscle weakness. Laboratory studies show hyperphosphatemia and hypo…
Practice question from Vitamins & Minerals (NEET PG Preparation Biochemistry), with the correct answer and a step-by-step solution.
medium · MCQ · Q-DE020A
A 50-year-old man with chronic renal failure presents with bone pain and proximal muscle weakness. Laboratory studies show hyperphosphatemia and hypocalcemia. Bone biopsy reveals osteomalacia and osteitis fibrosa cystica. Resistance to which of the following vitamins or its active metabolites is a hallmark contributor to renal osteodystrophy?
- A.Vitamin A
- B.Vitamin DCorrect answer
- C.Vitamin E
- D.Vitamin K
Solution
In chronic kidney disease, the failing kidneys cannot adequately express 1-alpha-hydroxylase, leading to a failure in converting 25-hydroxyvitamin D to its active form, 1,25-dihydroxyvitamin D (calcitriol), contributing to secondary hyperparathyroidism and renal osteodystrophy.
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