Virology · NEET PG Preparation Microbiology
A 32-year-old HIV-positive male presents with rapidly progressive dementia and visual disturbances. Magnetic resonance imaging of the brain shows asy…
Practice question from Virology (NEET PG Preparation Microbiology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-9EB3B7
A 32-year-old HIV-positive male presents with rapidly progressive dementia and visual disturbances. Magnetic resonance imaging of the brain shows asymmetric white matter lesions without mass effect or contrast enhancement. Polymerase chain reaction of the cerebrospinal fluid is positive for JC virus. This condition is caused by the reactivation of which type of viral genome?
- A.Double-stranded DNA, circularCorrect answer
- B.Single-stranded DNA, linear
- C.Double-stranded RNA, segmented
- D.Single-stranded positive-sense RNA, linear
Solution
JC virus is a member of the Polyomaviridae family, which possess a double-stranded, circular DNA genome. It causes progressive multifocal leukoencephalopathy (PML) in immunocompromised patients by lytic infection of oligodendrocytes.
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