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Virology · NEET PG Preparation Microbiology

A virology laboratory receives a specimen for viral culture from a patient with suspected viral hemorrhagic fever. The virus is known to be an envelo…

Practice question from Virology (NEET PG Preparation Microbiology), with the correct answer and a step-by-step solution.

hard · MCQ · Q-9FB26A

A virology laboratory receives a specimen for viral culture from a patient with suspected viral hemorrhagic fever. The virus is known to be an enveloped, negative-sense, single-stranded RNA virus with a segmented genome belonging to the Bunyaviridae family (specifically Hantavirus). Which of the following statements is true regarding viral replication of this group?

  1. A.Replication occurs entirely in the nucleus of the host cell
  2. B.Replication occurs in the cytoplasm, and viral assembly involves budding into the Golgi apparatusCorrect answer
  3. C.The genome acts directly as mRNA upon entry into the host cell cytoplasm
  4. D.Replication requires a reverse transcriptase enzyme encoded by the virion

Solution

Bunyaviruses are negative-sense, single-stranded RNA viruses with segmented genomes. Unlike most other negative-sense RNA viruses which bud at the plasma membrane, Bunyaviruses replicate in the cytoplasm and typically bud into the Golgi apparatus.

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