Breast & Endocrine Surgery · NEET PG Preparation Surgery

A 28-year-old male is evaluated for episodic headaches, diaphoresis, and severe hypertension. Biochemical evaluation reveals markedly elevated 24-hou…

Practice question from Breast & Endocrine Surgery (NEET PG Preparation Surgery), with the correct answer and a step-by-step solution.

medium · MCQ · Q-BAA982

A 28-year-old male is evaluated for episodic headaches, diaphoresis, and severe hypertension. Biochemical evaluation reveals markedly elevated 24-hour urinary metanephrines. Imaging localizes a 4 cm left adrenal mass. Which of the following preoperative medical preparations is mandatory prior to surgical resection of this tumor?

  1. A.Beta-blocker monotherapy followed immediately by surgery
  2. B.Alpha-adrenergic blockade followed by sodium and volume repletionCorrect answer
  3. C.High-dose glucocorticoid replacement therapy
  4. D.Immediate fine-needle aspiration cytology

Solution

The patient has a pheochromocytoma. Preoperative alpha-adrenergic blockade (e.g., phenoxybenzamine) is mandatory for 10-14 days prior to surgery to control blood pressure and expand the contracted intravascular volume. Beta-blockers should only be added after adequate alpha-blockade has been established to prevent paradoxical hypertensive crises.

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