Inhalational & Intravenous Anaesthetics · NEET PG Preparation Anaesthesia
A patient under general anesthesia maintained with sevoflurane and nitrous oxide suddenly develops an unexplained rise in end-tidal carbon dioxide (E…
Practice question from Inhalational & Intravenous Anaesthetics (NEET PG Preparation Anaesthesia), with the correct answer and a step-by-step solution.
medium · MCQ · Q-BCD1F7
A patient under general anesthesia maintained with sevoflurane and nitrous oxide suddenly develops an unexplained rise in end-tidal carbon dioxide (ETCO2), tachycardia, masseter muscle rigidity, and rapidly rising core body temperature. The most specific life-saving pharmacotherapy to administer immediately is:
- A.DantroleneCorrect answer
- B.Sugammadex
- C.Flumazenil
- D.Naloxone
Solution
The patient is presenting with classic signs of Malignant Hyperthermia (MH), a pharmacogenetic hypermetabolic disorder triggered by volatile halogenated anaesthetics and succinylcholine. Dantrolene is a skeletal muscle ryanodine receptor (RyR1) antagonist and the specific antidote used to treat MH.
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