CNS Drugs · NEET PG Preparation Pharmacology
A patient with generalized anxiety disorder is prescribed buspirone. Unlike benzodiazepines, buspirone lacks sedative, hypnotic, anticonvulsant, and…
Practice question from CNS Drugs (NEET PG Preparation Pharmacology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-C81809
A patient with generalized anxiety disorder is prescribed buspirone. Unlike benzodiazepines, buspirone lacks sedative, hypnotic, anticonvulsant, and muscle-relaxant properties. What is the primary mechanism of action of buspirone?
- A.Positive allosteric modulator at the GABA-A receptor
- B.Partial agonist at the 5-HT1A receptorCorrect answer
- C.Selective serotonin reuptake inhibitor
- D.Antagonist at central dopamine D2 receptors
Solution
Buspirone acts primarily as a partial agonist at brain 5-HT1A receptors. It has a slow onset of action (typically 1-2 weeks) and does not cause sedation, dependence, or cognitive impairment like benzodiazepines.
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