CNS Drugs · NEET PG Preparation Pharmacology
A 28-year-old woman with a history of bipolar disorder presents to the emergency department with coarse tremors, hyperreflexia, ataxia, and confusion…
Practice question from CNS Drugs (NEET PG Preparation Pharmacology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-F5685C
A 28-year-old woman with a history of bipolar disorder presents to the emergency department with coarse tremors, hyperreflexia, ataxia, and confusion. She recently started a new antihypertensive medication for mild blood pressure elevation. Which of the following drugs is most likely to have precipitated lithium toxicity?
- A.Amlodipine
- B.HydrochlorothiazideCorrect answer
- C.Metoprolol
- D.Hydralazine
Solution
Thiazide diuretics (such as hydrochlorothiazide) decrease the renal clearance of lithium by inducing proximal tubular sodium depletion, which leads to enhanced tubular reabsorption of lithium and subsequent toxicity.
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