Cardiovascular & Renal Drugs · NEET PG Preparation Pharmacology
A patient with refractory edema secondary to congestive heart failure is given a diuretic that acts on the collecting tubules by directly inhibiting…
Practice question from Cardiovascular & Renal Drugs (NEET PG Preparation Pharmacology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-CBE1FD
A patient with refractory edema secondary to congestive heart failure is given a diuretic that acts on the collecting tubules by directly inhibiting epithelial sodium channels (ENaC) independent of aldosterone. Which drug fits this description?
- A.Spironolactone
- B.Eplerenone
- C.AmilorideCorrect answer
- D.Mannitol
Solution
Amiloride (and triamterene) are potassium-sparing diuretics that directly block the epithelial sodium channels (ENaC) in the late distal convoluted tubule and collecting duct, independent of the presence of aldosterone. Spironolactone and eplerenone are competitive mineralocorticoid receptor antagonists.
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