Renal & GI Pathology · NEET PG Preparation Pathology
A 10-year-old boy presents with periorbital edema, generalized swelling, and heavy proteinuria. Renal biopsy shows normal glomeruli on light microsco…
Practice question from Renal & GI Pathology (NEET PG Preparation Pathology), with the correct answer and a step-by-step solution.
easy · MCQ · Q-0B16E7
A 10-year-old boy presents with periorbital edema, generalized swelling, and heavy proteinuria. Renal biopsy shows normal glomeruli on light microscopy, but electron microscopy reveals diffuse effacement of podocyte foot processes. There are no immune deposits. Which of the following is the most appropriate first-line therapy?
- A.Cyclophosphamide
- B.CorticosteroidsCorrect answer
- C.Plasmapheresis
- D.Rituximab
Solution
The clinical presentation and electron microscopic findings (diffuse effacement of foot processes with normal light microscopy) are classic for Minimal Change Disease (MCD), the most common cause of nephrotic syndrome in children. MCD is typically highly responsive to corticosteroid therapy.
More from Renal & GI Pathology
- A 45-year-old man presents with gross hematuria and hypertension. His father died of end-stage renal disease due to an inherited condition.…
- A 55-year-old chronic smoker presents with painless gross hematuria and a left-sided varicocele that does not recumbent. Radical nephrectom…
- A 32-year-old woman presents with recurrent episodes of bloody diarrhea, abdominal pain, and low-grade fever. Colonoscopy reveals continuou…
- A 60-year-old man presents with progressive dysphagia for both solids and liquids, along with significant weight loss. Endoscopy reveals a…
Practise more Pathology
Sign up free for adaptive practice on this chapter, with instant feedback and hints on every question.
Start practising freeFree to start · No credit card needed