Renal & GI Pathology · NEET PG Preparation Pathology
A 60-year-old man presents with progressive dysphagia for both solids and liquids, along with significant weight loss. Endoscopy reveals a mass at th…
Practice question from Renal & GI Pathology (NEET PG Preparation Pathology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-DAE617
A 60-year-old man presents with progressive dysphagia for both solids and liquids, along with significant weight loss. Endoscopy reveals a mass at the gastroesophageal junction. Biopsy shows malignant glandular structures with mucin production, occurring in a background of columnar metaplasia of the lower esophagus. What is the most important risk factor for this lesion?
- A.Achalasia
- B.Chronic alcoholism
- C.Gastroesophageal reflux disease (GERD)Correct answer
- D.Tobacco smoking
Solution
The clinical vignette describes esophageal adenocarcinoma, which typically arises in the lower third of the esophagus from Barrett esophagus. Barrett esophagus is a complication of chronic gastroesophageal reflux disease (GERD) where squamous epithelium is replaced by metaplastic columnar epithelium with goblet cells.
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