General Pharmacology · NEET PG Preparation Pharmacology
A novel competitive antagonist is administered to a patient. Which of the following best describes the effect of a competitive antagonist on the agon…
Practice question from General Pharmacology (NEET PG Preparation Pharmacology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-707409
A novel competitive antagonist is administered to a patient. Which of the following best describes the effect of a competitive antagonist on the agonist dose-response curve?
- A.Downward shift of the curve with a decrease in maximal efficacy
- B.Parallel shift of the curve to the right without a change in maximal efficacyCorrect answer
- C.Parallel shift of the curve to the left with an increase in potency
- D.No change in the curve unless a partial agonist is used
Solution
A competitive antagonist binds reversibly to the same receptor site as the agonist, increasing the concentration of agonist required to produce the same response. This results in a parallel shift of the agonist dose-response curve to the right, with no change in the maximal efficacy (), provided sufficient agonist is added.
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