General Pharmacology · NEET PG Preparation Pharmacology
Which of the following transporters is primarily responsible for the ATP-dependent efflux of drugs across the blood-brain barrier and intestinal muco…
Practice question from General Pharmacology (NEET PG Preparation Pharmacology), with the correct answer and a step-by-step solution.
medium · MCQ · Q-F59646
Which of the following transporters is primarily responsible for the ATP-dependent efflux of drugs across the blood-brain barrier and intestinal mucosa, often leading to multidrug resistance?
- A.Organic anion transporter 1 (OAT1)
- B.P-glycoprotein (MDR1 / ABCB1)Correct answer
- C.Glucose transporter 4 (GLUT4)
- D.Serotonin transporter (SERT)
Solution
P-glycoprotein (encoded by the MDR1 or ABCB1 gene) is an ATP-binding cassette (ABC) transporter that pumps various xenobiotics and drugs out of cells, serving a protective barrier role in the gut, blood-brain barrier, and kidney, and contributing to multidrug resistance in cancer.
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