Paediatric Cardiology & Nephrology · NEET PG Preparation Paediatrics
A 5-year-old boy presents with periorbital edema, generalized swelling, and frothy urine for the last 5 days. Laboratory investigations reveal massiv…
Practice question from Paediatric Cardiology & Nephrology (NEET PG Preparation Paediatrics), with the correct answer and a step-by-step solution.
easy · MCQ · Q-948BAE
A 5-year-old boy presents with periorbital edema, generalized swelling, and frothy urine for the last 5 days. Laboratory investigations reveal massive proteinuria (> 40 mg/m²/hour), serum albumin of 2.1 g/dL, and hyperlipidemia. Serum creatinine is normal, and complement levels (C3) are normal. What is the most common underlying renal histopathology in this age group?
- A.Membranoproliferative glomerulonephritis
- B.Minimal change diseaseCorrect answer
- C.Focal segmental glomerulosclerosis
- D.Membranous nephropathy
Solution
The clinical picture of steroid-sensitive nephrotic syndrome with normal renal function and normal complements in a 5-year-old child is most commonly caused by Minimal Change Disease (MCD), accounting for about 80-85% of cases in children aged 1-10 years.
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